New doctors' DNA ages six times faster than normal in first year: Long work hours of intern year associated with accelerated shortening of telomere regions of chromosomes -- ScienceDaily
Published online in the journal Biological Psychiatry, the new study is the first to measure telomere length before and after individuals faced a common prolonged intense experience. It involved 250 interns from around the country who volunteered for the Intern Health Study, based at the University of Michigan, and a comparison group of college students from U-M.
"Research has implicated telomeres as an indicator of aging and disease risk, but these longitudinal findings advance the possibility that telomere length can serve as a biomarker that tracks effects of stress, and helps us understand how stress gets 'under the skin' and increases our risk for disease," says Srijan Sen, M.D., Ph.D., the U-M neuroscientist and psychiatrist who is the study's senior author and heads the Intern Health Study.
He adds, "It will be important to study how telomere changes play out in larger groups of medical trainees, and in other groups of people subjected to specific prolonged stresses such as military training, graduate studies in the sciences and law, working for startup companies, or pregnancy and the first months of parenting."