Gaining or losing weight alters molecular profile in humans -- ScienceDaily
Snyder and his colleagues found that even with modest weight gain -- about 6 pounds -- the human body changed in dramatic fashion at the molecular level. Bacterial populations morphed, immune responses and inflammation flared, and molecular pathways associated with heart disease activated. But that's not the end of the story. When study participants lost the weight, most of the rest of the body's systems recalibrated back to their original states, the study found.