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Influence of Cerebral Blood Flow on Central Sleep Apnea at High Altitude | Sleep | Oxford Academic

Carbon dioxide (CO2) therapy has been shown to reduce the severity of CSA when administered constantly in a normal volunteer model6 and more potently in a mathematical model when administered dynamically.7 However, neither approach has been adopted into clinical practice. The pathogenesis of CSA remains incompletely understood, thus a better understanding of the underlying mechanisms/ pathogenesis of CSA may provide improved treatment options.

Cannabinoid May Be First Drug for Sleep Apnea

"Based on a series of animal investigations, we proposed that drugs which dampen afferent vagal feedback to the medulla may be effective in stabilizing respiratory pattern generation and increasing activation of upper airway dilating muscles during sleep," the authors note. Dr Zee added that larger studies will be necessary to shed more light on dronabinol's specific clinical applications in sleep apnea. "Due to the phase 2 study, it would be premature to comment on how the compound will be used in clinical settings. Larger studies that can be generalized to the obstructive sleep apnea population are needed. It could conceivably be used in patients who fail CPAP, [and] other approved therapies, such as oral appliances or as adjunctive therapy," she said.

Cannabinoid May Be First Drug for Sleep Apnea

The primary endpoint was change from baseline in AHI after 6 weeks of treatment. The study showed significant improvements in the 2.5-mg group, with a reduction of 10.5 events per hour (P = .02), and in the 10-mg group, with a reduction of 12.9 events per hour (P = .004), in rapid eye movement (REM) as well as non-REM sleep, after adjustment for factors including age, race, ethnicity, and baseline AHI. No significant changes were observed in the placebo group after adjustment, and the differences in improvement between the 2.5- and 10-mg groups were not statistically significant.

Central Sleep Apnea – Sleep Apnea

CSA frequently occurs among people who are seriously ill from other causes: chronic heart failure; diseases of and injuries to the brainstem, the upper terminus of the spine, which controls breathing; Parkinson’s disease; stroke; kidney failure; even severe arthritis with degenerative changes to the cervical spine and base of the skull. It is seen among users of opiates. And there is idiopathic CSA, which simply means the cause is unknown. “For idiopathic apnea, the outlook is generally favorable,” notes Medline Plus, an online information service of the National Library of Medicine and the National Institutes of Health.

The Association of Testosterone Levels with Overall Sleep Quality, Sleep Architecture, and Sleep-Disordered Breathing

Thus, it remains unclear whether restoration to young adult testosterone levels is protective or harmful to sleep patterns in elderly men. No large population-based studies have reported the association of endogenous testosterone levels with objectively measured sleep parameters in older community-dwelling men or examined whether any observed associations are independent of age, body mass index (BMI), and other potential covariates. We report here the independent association of baseline endogenous total and bioavailable testosterone levels in 1312 relatively healthy community-dwelling older men who had overnight sleep duration, sleep architecture, and sleep-disordered breathing measured objectively an average of 3.4 yr later.