Recent quotes:

Anti-aging protein alpha Klotho's molecular structure revealed -- ScienceDaily

One of the major, paradigm-changing findings revealed by solving the protein complex structure is that the circulating form of soluble a-Klotho can actually serve as a co-receptor for FGF23. Thus, the soluble form of a-Klotho can go to any cell in the body and act as a co-receptor for FGF23, rendering every cell a possible target of FGF23, representing a major paradigm shift. "a-Klotho researchers in cancer, aging, neurologic, cardiovascular, and kidney disease will benefit from this research," Dr. Moe said. "The knowledge of the structure of the protein, along with its molecular binding partners, will enable us to greatly advance the understanding of how a-Klotho works and also how to best design therapeutic strategies and novel agents that can either activate or block FGF23-a-Klotho interaction and signaling as needed."

Hiking for a month transforms dude's metabolism

The question I had before my thru-hike was this: Would walking all day, every day, for a month improve my metabolic efficiency when I run at a high intensity? In other words, could I become a better athlete by simply walking?  Before the trip, I was burning 66 percent fat and 34 percent carbs during low-intensity exercise or any activity during which I had a heart rate of 112 bpm. At a slow long-run pace, with a heart rate of 145 bpm, I was burning 52 percent fat and 48 percent carbohydrates. My crossover point—the heart rate at which I was burning carbs and fat equally—was 153 bpm, or a moderate-to-slow running pace.  After the trip, I was, as my test administrator at Real Rehab in Seattle put it, “a fat-burning machine.” At 110 bpm, I was burning 91 percent fat and 9 percent carbohydrates. At 145 bpm, I was burning 70 percent fat and 30 percent carbohydrates. My crossover point had moved to 168 bpm, which I reached at a fairly fast running pace. And even at my maximum heart rate (184 bpm), I was still getting a quarter of my energy from fat.   What does this mean? I can now go on long runs without consuming gels and other foods, or at least a significantly reduced amount. Also, the next time I go backpacking, I will be able to carry less weight in my pack because each gram of fat has nine calories, while a gram of carbohydrate or protein provides less than half that energy—around four calories. This means I can carry more high-fat foods like nuts and cheese, while cutting way back on sugary high-carb snacks like energy bars and candy. Plus, if I run low on food near the end of a trip (something that happened several times between resupplies during our thru-hike), my body will be able to run just fine on body fat until I make it to the next rest stop.

Research has found that walking for two hours a day could cut inches off your waistline | UK | News | Daily Express

Replacing sitting for two hours a day with standing led to an 11 per cent lower BMI on average and a three-inch smaller waist. Average blood sugar levels also fell by 11 per cent. Dr Healy said: "These findings provide important preliminary evidence that strategies to increase the amount of time spent standing or walking rather than sitting may benefit the heart and metabolism of many people.