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Good news for coffee lovers: Daily coffee may benefit the heart: Drinking two to three cups a day was associated with greatest heart benefits -- ScienceDaily

For the first study, researchers examined data from 382,535 individuals without known heart disease to see whether coffee drinking played a role in the development of heart disease or stroke during the 10 years of follow up. Participants' average age was 57 years and half were women. In general, having two to three cups of coffee a day was associated with the greatest benefit, translating to a 10%-15% lower risk of developing coronary heart disease, heart failure, a heart rhythm problem, or dying for any reason. The risk of stroke or heart-related death was lowest among people who drank one cup of coffee a day. Researchers did observe a U-shaped relationship with coffee intake and new heart rhythm problems. The maximum benefit was seen among people drinking two to three cups of coffee a day with less benefit seen among those drinking more or less.

Agatston score | Radiology Reference Article | Radiopaedia.org

Agatston score is a semi-automated tool to calculate a score based on the extent of coronary artery calcification detected by an unenhanced low-dose CT scan, which is routinely performed in patients undergoing cardiac CT. Due to an extensive body of research, it allows for early risk stratification as patients with a high Agatston score (>160) have an increased risk for a major adverse cardiac event (MACE) 2. Although it does not allow for the assessment of soft non-calcified plaques, it has shown a good correlation with contrast-enhanced CT coronary angiography 1.

Growing evidence of vitamin K benefits for heart health -- ScienceDaily

There are two types of vitamin K found in foods we eat: vitamin K1 comes primarily from green leafy vegetables and vegetable oils while vitamin K2 is found in meat, eggs and fermented foods such as cheese. The study found that people with the highest intakes of vitamin K1 were 21 percent less likely to be hospitalised with cardiovascular disease related to atherosclerosis. For vitamin K2, the risk of being hospitalised was 14 percent lower. This lower risk was seen for all types of heart disease related to atherosclerosis, particularly for peripheral artery disease at 34 percent.

AI can predict early death risk: Algorithm using echocardiogram videos of the heart outperforms other predictors of mortality -- ScienceDaily

Researchers at Geisinger have found that a computer algorithm developed using echocardiogram videos of the heart can predict mortality within a year. The algorithm -- an example of what is known as machine learning, or artificial intelligence (AI) -- outperformed other clinically used predictors, including pooled cohort equations and the Seattle Heart Failure score. The results of the study were published in Nature Biomedical Engineering. "We were excited to find that machine learning can leverage unstructured datasets such as medical images and videos to improve on a wide range of clinical prediction models," said Chris Haggerty, Ph.D., co-senior author and assistant professor in the Department of Translational Data Science and Informatics at Geisinger. Imaging is critical to treatment decisions in most medical specialties and has become one of the most data-rich components of the electronic health record (EHR). For example, a single ultrasound of the heart yields approximately 3,000 images, and cardiologists have limited time to interpret these images within the context of numerous other diagnostic data. This creates a substantial opportunity to leverage technology, such as machine learning, to manage and analyze this data and ultimately provide intelligent computer assistance to physicians.

AI technique detects heart failure from a single heartbeat with 100% accuracy - ScienceBlog.com

Dr Massaro said: “We trained and tested the CNN model on large publicly available ECG datasets featuring subjects with CHF as well as healthy, non-arrhythmic hearts. Our model delivered 100% accuracy: by checking just one heartbeat we are able detect whether or not a person has heart failure. Our model is also one of the first known to be able to identify the ECG’ s morphological features specifically associated to the severity of the condition.”

The Week That Wasn't: Kimchi, Light Therapy, FDA Bleach Warning

After conducting mouse experiments, the researchers recruited healthy human volunteers, exposed them to intense light for 30 minutes, and analyzed protein levels in their blood to confirm that the biological changes from intense light that they observed in mice also occurred in people. The researchers posit that intense light therapy might be helpful for treating cardiovascular disease.

Next for Apple Watch: a clinical trial with J&J to track heart health - STAT

Typically, clinical trials use their own research infrastructure to track how patients do, but the HEARTLINE trial will plug into insurance claims databases to track patients. This approach, called a pragmatic clinical trial, could be cheaper and more efficient than the way studies are conducted now, without sacrificing the clarity and certainty that comes from having a control group in a study. But this is also risky: Using insurance claims data this way is new and untested. “It’s certainly a vast and gross departure form the bricks and mortar model,” said Gibson. “This is one of the most exciting things, the idea that you’re going to find participants through the media, the news, potentially through insurers and even health care providers.”

Synchronizing Gait with Cardiac Cycle Phase Alters Heart Rat... : Medicine & Science in Sports & Exercise

Finally, if diastolic stepping is truly advantageous for exercise performance, we wondered if there is any natural tendency for elite runners to step diastolically without prompting. We observed that 3 of the 10 subjects stepped accurately at the diastolic target timing (45% ± 15% RRI) during a substantial portion of their final, unprompted (silent) control period (e.g., see Fig. 2B). In one of those cases, the subject was guided to systolic step timing during the final prompted period but naturally reverted to stepping during diastole when the auditory prompt was removed. By comparison, none of the subjects stepped at a consistent systolic phase during the free stepping control stages. These anecdotal observations are also consistent with the findings of earlier authors, including Niizeki (10), which suggested that the heart automatically adjusts its timing, when HR = SR, to prevent ventricular systole from coinciding with maximal peripheral skeletal muscle contraction.

Weightlifting is good for your heart and it doesn't take much -- ScienceDaily

Less than an hour of weekly resistance exercise (compared with no resistance exercise) was associated with a 29 percent lower risk of developing metabolic syndrome, which increases risk of heart disease, stroke and diabetes. The risk of hypercholesterolemia was 32 percent lower. The results for both studies also were independent of aerobic exercise.

Under 40 With High Blood Pressure? Be Wary of Heart Risks - The New York Times

About half the group had normal blood pressure of 120/80 or lower. Compared with them, those with elevated pressure — 120-129/80 or higher — were 67 percent more likely to have had cardiovascular problems. People with readings of 130-139/80-89 had a 75 percent increased risk, and those with readings above 140/90 were three and a half times as likely to have some type of cardiovascular disease.

An End to Arachnophobia Just a Heartbeat Away - Neuroscience News

For one group of patients, pictures of spiders were presented in-time with heartbeats (during the signalling of cardiac arousal), while for another patient group, pictures of spiders were presented in-between heartbeats. A third control group saw spiders randomly in the therapy sessions. Although there was some improvement among all patients, as you would expect in exposure therapy, those individuals exposed to spiders in-time with their own heartbeats showed a greater reductions in self-reported fear of spiders, anxiety levels and their physiological responses to spiders.

Can wearable technology identify irregular heart rhythms? -- ScienceDaily

Researchers at Stanford Medicine, in collaboration with Apple, launched the Apple Heart Study last November to determine whether a mobile app that uses the optical sensor on the Apple Watch to analyze pulse rate data can identify atrial fibrillation. The condition, which is characterized by an irregular heartbeat, often remains hidden because many people don't experience symptoms. Atrial fibrillation can increase the risk of stroke and heart failure. A paper to be published online Nov. 1 in the American Heart Journal describes the design of this unique clinical trial, the largest screening study on atrial fibrillation ever done. Enrollment, which was conducted through an iPhone app, is now closed. The study has entered the final phase of data collection and will be completed early next year, the researchers said. The Stanford team is led by principal investigators Mintu Turakhia, MD, associate professor of cardiovascular medicine, and Marco Perez, MD, assistant professor of cardiovascular medicine, and by study chair Kenneth Mahaffey, MD, professor of cardiovascular medicine. "We hope this study will help us better understand how wearable technologies can inform precision health," said Lloyd Minor, MD, dean of the School of Medicine. "These new tools, which have the potential to predict, prevent and manage disease, are finally within our reach."

Do unexpected panic attacks occur spontaneously? - PubMed - NCBI

Significant patterns of instability across a number of autonomic and respiratory variables were detected as early as 47 minutes before panic onset. The final minutes before onset were dominated by respiratory changes, with significant decreases in tidal volume followed by abrupt carbon dioxide partial pressure increases. Panic attack onset was characterized by heart rate and tidal volume increases and a drop in carbon dioxide partial pressure. Symptom report was consistent with these changes. Skin conductance levels were generally elevated in the hour before, and during, the attacks. Changes in the matched control periods were largely absent.

It's not just for kids -- even adults appear to benefit from a regular bedtime: Adults with varied sleep-wake times weigh more, have higher blood sugar, risk of disease -- ScienceDaily

Of all three measures, however, regularity was the best at predicting someone's heart and metabolic disease risk, the researchers found. As one might expect, irregular sleepers experienced more sleepiness during the day and were less active -- perhaps because they were tired, Lunsford-Avery said. Researchers plan to conduct more studies over longer periods in hopes of determining how biology causes changes in sleep regularity and vice-versa. "Perhaps there's something about obesity that disrupts sleep regularity," Lunsford-Avery said. "Or, as some research suggests, perhaps poor sleep interferes with the body's metabolism which can lead to weight gain, and it's a vicious cycle. With more research, we hope to understand what's going on biologically, and perhaps then we could say what's coming first or which is the chicken and which is the egg."

Researchers Identify Molecule With Anti-Aging Effects On Vascular System - News Hub -

In this study, the research team explores the link between calorie restriction (eating less or fasting) and delaying aging, which is unknown and has been poorly studied. The findings are published in the journal Molecular Cell. The researchers identified an important, small molecule that is produced during fasting or calorie restriction conditions. The molecule, β-Hydroxybutyrate, is one type of a ketone body, or a water-soluble molecule that contains a ketone group and is produced by the liver from fatty acids during periods of low food intake, carbohydrate restrictive diets, starvation and prolonged intense exercise. “We found this compound, β-Hydroxybutyrate, can delay vascular aging,” Zou said. “That’s actually providing a chemical link between calorie restriction and fasting and the anti-aging effect. This compound can delay vascular aging through endothelial cells, which line the interior surface of blood vessels and lymphatic vessels. It can prevent one type of cell aging called senescence, or cellular aging.” Senescent cells can no longer multiple and divide. The researchers found β-Hydroxybutyrate can promote cell division and prevent these cells from becoming old. Because this molecule is produced during calorie restriction or fasting, when people overeat or become obese this molecule is possibly suppressed, which would accelerate aging.

Take a vacation -- it could prolong your life -- ScienceDaily

Participants were randomised into a control group (610 men) or an intervention group (612 men) for five years. The intervention group received oral and written advice every four months to do aerobic physical activity, eat a healthy diet, achieve a healthy weight, and stop smoking. When health advice alone was not effective, men in the intervention group also received drugs recommended at that time to lower blood pressure (beta-blockers and diuretics) and lipids (clofibrate and probucol). Men in the control group received usual healthcare and were not seen by the investigators. As previously reported, the risk of cardiovascular disease was reduced by 46% in the intervention group compared to the control group by the end of the trial. However, at the 15-year follow-up in 1989 there had been more deaths in the intervention group than in the control group. The analysis presented today extended the mortality follow-up to 40 years (2014) using national death registers and examined previously unreported baseline data on amounts of work, sleep, and vacation. The researchers found that the death rate was consistently higher in the intervention group compared to the control group until 2004. Death rates were the same in both groups between 2004 and 2014.

The heart: Digital or analog? Researchers shed dramatic light on heart bioelectricity disorders -- ScienceDaily

"Sodium channels are literally stuck together between cells in way that seems to ensure that the firing of channels in one cell sparks partnering channels in the neighboring cell," Gourdie said. "The molecular machinery seems to be in place for bioelectrical signals to step between heart cells, not wholly unlike how impulses jump between nerve cells in a stepping-stone-like manner at neural synapses."

Why Sitting May Be Bad for Your Brain - The New York Times

It was equally apparent when people broke up their sitting after two hours, although blood flow rose during the actual walking break. It soon sank again, the ultrasound probes showed, and was lower at the end of that session than at its start. But brain blood flow rose slightly when the four hours included frequent, two-minute walking breaks, the scientists found. Interestingly, none of these changes in brain blood flow were dictated by alterations in breathing and carbon dioxide levels, the scientists also determined. Carbon dioxide levels had remained steady before and after each session.

Pay to play

Exercise-based cardiac rehab programs have proven to reduce mortality in ischemic heart disease patients by 30 percent, but buy-in to excersise regiments has been historically low, according to the study's authors. They also noted that there has been a robust discussion around wearables’ ability to remotely monitor health behaviors, but little evidence that the devices lead to an improved behavior over a long period of time. However, past studies have showed that money does motivate behaviors.

Virtual coaches, fitness trackers help patients stay fit after cardiac rehab: Small pilot study suggests virtual oversight keeps patients motivated to exercise -- ScienceDaily

The 12-week mobile health, or mHealth, program not only kept cardiac rehab patients from losing ground, it appeared to help them maintain and even gain fitness. The researchers have published their findings in the American Heart Journal and are now looking to scale up the study with a larger group of patients. "The benefits of a cardiac rehab program are well-established, but the gains tend to be temporary," said senior author William Kraus, M.D., who led the project as part of the Duke Molecular Physiology Institute. "Good habits are hard to maintain for a lot of people once they are on their own and no longer have someone overseeing their progress."

This is your brain on exercise: Vigorous exercise boosts critical neurotransmitters, may help restore mental health -- ScienceDaily

The researchers measured GABA and glutamate levels in two different parts of the brain immediately before and after three vigorous exercise sessions lasting between eight and 20 minutes, and made similar measurements for a control group that did not exercise. Glutamate or GABA levels increased in the participants who exercised, but not among the non-exercisers. Significant increases were found in the visual cortex, which processes visual information, and the anterior cingulate cortex, which helps regulate heart rate, some cognitive functions and emotion. While these gains trailed off over time, there was some evidence of longer-lasting effects. "There was a correlation between the resting levels of glutamate in the brain and how much people exercised during the preceding week," Maddock said. "It's preliminary information, but it's very encouraging." These findings point to the possibility that exercise could be used as an alternative therapy for depression. This could be especially important for patients under age 25, who sometimes have more side effects from selective serotonin reuptake inhibitors (SSRIs), anti-depressant medications that adjust neurotransmitter levels.

A heartbeat-like vibration can reduce the anxiety associated with public speaking

“Rather than worrying about measuring physiological variables, such as heart rate, steps taken and burnt calories through the use of wearables, we can think of new ways to exploit this technology by making it more embodied, more embedded and more affective,” Tsakiris said. “We can use fundamental biological signals to change the way we think and feel.”

Strength is Money in the Bank | Mark Rippetoe

All the “cardio” in the world will do nothing to maintain your muscle mass, while effective strength training both grows muscle mass and keeps your heart and lungs in shape. If you have enough sense to know you must devote some time to exercise, strength training is the far more logical way to spend that time.

CBT plus video games plus heart rate monitors

In a subsequent outpatient study the researchers randomized 20 youth to 10 cognitive behavior therapy sessions and videogame therapy that required them to control their heart rate, and 20 youth to CBT with the same videogame but not linked to heart rates. All the adolescents had anger or aggression problems, said Dr. Gonzalez-Heydrich, who was senior author of the study. Therapists interviewed the children’s primary caregiver before and two weeks after their last therapy session. They found the children’s ratings on aggression and opposition were reduced much more in the group that played the game with the built-in biofeedback. The ratings for anger went down about the same in both groups. The findings were presented at the American Academy of Child and Adolescent Psychiatry conference in 2015. The study is currently under review for publication.

Wearing a 'heart' on your sleeve can reduce stress -- ScienceDaily

To test the efficacy of doppel, the researchers exposed volunteers to a socially stressful situation and measured their physiological arousal and their reported anxiety levels. In a controlled, single-blind study, two groups of participants were asked to prepare a public speech -- a widely used psychological task that consistently increases stress. All participants wore the device on their wrist and a cover story was used to suggest to participants that the device was measuring blood pressure during the anticipation of the task. Importantly, for only one of the two groups of participants, the device was turned on and delivered a heartbeat-like vibration at a slower frequency than the participants' resting heart rate, while they were preparing their speech. The researchers measured both physiological arousal and subjective reports of anxiety. The use of doppel had a tangible and measurable calming effect across both physiological and psychological levels. Only the participants who felt the heartbeat-like vibration displayed lower increases in skin conductance responses and lower anxiety levels. "Wearable devices are becoming ubiquitous in everyday life, but across the board their primary aim is to quantify our activity. The results we got suggest that, rather than measuring ourselves, we can instead harvest our natural responses to heartbeat like rhythms in ways that can assist people in their everyday life." said Professor Tsakiris.

How walking benefits the brain: Researchers show that foot's impact helps control, increase the amount of blood sent to the brain -- ScienceDaily

"New data now strongly suggest that brain blood flow is very dynamic and depends directly on cyclic aortic pressures that interact with retrograde pressure pulses from foot impacts," the researchers wrote. "There is a continuum of hemodynamic effects on human brain blood flow within pedaling, walking and running. Speculatively, these activities may optimize brain perfusion, function, and overall sense of wellbeing during exercise." "What is surprising is that it took so long for us to finally measure these obvious hydraulic effects on cerebral blood flow," first author Ernest Greene explained. "There is an optimizing rhythm between brain blood flow and ambulating. Stride rates and their foot impacts are within the range of our normal heart rates (about 120/minute) when we are briskly moving along."