A Test That Finds the Perfect Drug? - The Atlantic“Psychiatry remains the only discipline of medicine that has no test to predict treatment response,” said Evian Gordon, the founder of one such company, Brain Resource. “This is providing, for the first time, an objective step as to which drug might be responsive.”
Cardiovascular fitness, cortical plasticity, and aging. - PubMed - NCBICardiovascular fitness is thought to offset declines in cognitive performance, but little is known about the cortical mechanisms that underlie these changes in humans. Research using animal models shows that aerobic training increases cortical capillary supplies, the number of synaptic connections, and the development of new neurons. The end result is a brain that is more efficient, plastic, and adaptive, which translates into better performance in aging animals. Here, in two separate experiments, we demonstrate for the first time to our knowledge, in humans that increases in cardiovascular fitness results in increased functioning of key aspects of the attentional network of the brain during a cognitively challenging task. Specifically, highly fit (Study 1) or aerobically trained (Study 2) persons show greater task-related activity in regions of the prefrontal and parietal cortices that are involved in spatial selection and inhibitory functioning, when compared with low-fit (Study 1) or nonaerobic control (Study 2) participants. Additionally, in both studies there exist groupwise differences in activation of the anterior cingulate cortex, which is thought to monitor for conflict in the attentional system, and signal the need for adaptation in the attentional network. These data suggest that increased cardiovascular fitness can affect improvements in the plasticity of the aging human brain, and may serve to reduce both biological and cognitive senescence in humans.
How each generation gets the drugs it deserves | Aeon Essays‘This is a big shift from the old model,’ says Cowles. ‘It used to be: “I am Henry. I am ill in some way. A pill can help me get back to being Henry, and then I’m off it.” Whereas now: “I am only Henry when I’m on my meds.” Between 1980, 2000, and now, the proportion of people on that kind of maintenance pill with no end in sight is just going to keep going up and up.’
How each generation gets the drugs it deserves | Aeon EssaysBut, Cowles argues, one might just as easily say that ‘these drugs were created with various sub-populations in mind and they end up making available a new kind of housewife or a new kind of working woman, who is medicated in order to enable this kind of lifestyle’. In short, Cowles says: ‘The very image of the depressed housewife emerges only as a result of the possibility of medicating that.’
Abuse of ADHD drugs following path of opioidsMeanwhile, among those 26 and older, recreational use of Adderall, an amphetamine, rose fourfold, from 345,000 people in 2006 to 1.4 million in 2014, according to the latest available federal data. In emergency departments around the country, the number of cases involving two common ADHD drugs nearly quadrupled over seven years. And at morgues in Florida, a bellwether state for drug abuse problems, overdose deaths involving amphetamines increased more than 450% between 2008 and 2014.
Do ADHD Drugs Take a Toll on the Brain? - Scientific AmericanResearch hints that hidden risks might accompany long-term use of the medicines that treat attention-deficit hyperactivity disorder
Adhd and Temporality: A Desynchronized Way of Being in the World. - PubMed - NCBIADHD is, I argue, an impairment in sense of time and a matter of difference in rhythm; it can be understood as a certain being in the world, or more specifically, as a disruption in the experience of time and a state of desynchronization and arrhythmia. Through excerpts of interviews with adults diagnosed with ADHD and observations, I illustrate how impairment in time is manifested in an embodied experience of being out of sync. I suggest that the experience of ADHD is characterized as 1) an inner restlessness and bodily arrhythmia; 2) an intersubjective desynchronization between the individual and its surroundings; and 3) a feeling of lagging behind socially due to difficulties in social skills. In closing, I argue that an increasingly accelerating society is augmenting the experience of being out of sync rather than eliminating it.
Generation Adderall - The New York TimesDuring the first weeks of finally giving up Adderall, the fatigue was as real as it had been before, the effort required to run even a tiny errand momentous, the gym unthinkable. The cravings were a force of their own: If someone so much as said “Adderall” in my presence, I would instantly begin to scheme about how to get just one more pill. Or maybe two. I was anxious, terrified I had done something irreversible to my brain, terrified that I was going to discover that I couldn’t write at all without my special pills. I didn’t yet know that it would only be in the amphetamine-free years to follow that my book would finally come together.
Rumor: Doctor Prescribes Donald Trump "Cheap Speed"Rumors of Trump’s predilection for stimulants first started really popping up in 1992, when Spy magazine wrote, “Have you ever wondered why Donald Trump has acted so erratically at times, full of manic energy, paranoid, garrulous? Well, he was a patient of Dr. [Joseph] Greenberg’s from 1982 to 1985.” At the time, Dr. Greenberg was notorious for allegedly doling out prescription stimulants to anyone who could pay.
Persistent ADHD associated with overly critical parents: High levels of criticism over time related to continuation of symptoms, study says -- ScienceDailyParents were asked to talk about their relationship with their child uninterrupted for five minutes. Audio recordings of these sessions were then rated by experts for levels of criticism (harsh, negative statements about the child, rather than the child's behavior) and emotional over-involvement (overprotective feelings toward the child). Measurements were taken on two occasions one year apart. Only sustained parental criticism (high levels at both measurements, not just one) was associated with the continuance of ADHD symptoms in the children who had been diagnosed with ADHD. "The novel finding here is that children with ADHD whose families continued to express high levels of criticism over time failed to experience the usual decline in symptoms with age and instead maintained persistent, high levels of ADHD symptoms," said Musser.
Dopamine and memoryIn 2015, a systematic review and a meta-analysis of high quality clinical trials found that, when used at low (therapeutic) doses, stimulants produce unambiguous improvements in working memory, episodic memory, and inhibitory control in adults.
Distractibility trait predisposes some to attentional lapses -- ScienceDaily"Everyone, including the highly distractible people , who reported higher levels of ADHD symptoms and who responded up to 41% slower when the cartoon distractor was present, benefited from increasing the task difficulty, which may be contrary to common expectations," says Lavie.
Running as medicine for ADDBack in the early '80s, a marathoner came to me and said, look, I think I have adult-onset attention deficit disorder[…]the guy was - had a dual appointment at MIT and Harvard as a professor, was a MacArthur Fellow, had all the credentials in the world; and he was a marathoner. And he had to stop marathoning because he hurt his knee and couldn't run his typical seven to eight miles a day. So he said that at first, he got depressed, which happens to most marathoners. But secondly, after his depression resolved, he couldn't pay attention. He was like a child with attention deficit disorder - was always off in dreamland or would forget things, would get aggressive too easily, ignored his friends; all the things that we see in attention deficit disorder. […]I put him on medicine and that helped quite a lot but then, eventually, he got back to running, and he dropped the medicine because it was no longer necessary. And that's what we see at times with many of the people who have attentional issues or mood issues; that exercise can be self-medicating.
Ben Bradlee had trouble focusingMr. Bradlee had a notoriously short attention span. He rarely dug into the details of an issue himself, leaving that to the people he had hired. He managed The Post newsroom with a combination of viscera and intellect, often judging people by his personal reaction to them. He or she “makes me laugh” was perhaps Mr. Bradlee’s greatest compliment. He never enjoyed the minutiae of management and spent as little time on administrative work as he could get away with.
Exercise Is ADHD Medication
The study, published April 22 in the journal Psychological Science, included 108 adults. They took either Ritalin or a placebo an hour before they attempted two consecutive computer-based tasks that tested their self-control. The participants who took Ritalin retained higher levels of self-control in the second test than those who took the placebo. The results indicate that Ritalin can help prevent depletion of self-control, the researchers said. The drug may do this by giving a boost to specific brain circuits that are normally weakened after maintaining self-control for long periods.