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When muscles weaken with age -- ScienceDaily

Working with our colleagues from the University of Aachen, we first systematically surveyed the changes taking place in the peripheral nerves of people aged between 65 and 79," Rudolf Martini describes his team's approach. During this, the researchers encountered an increased number of macrophages in the samples. Macrophages are cells of our body's immune system that engulf, digest and dispose microbes, foreign substances, cellular debris, aging cells etc. They set inflammatory responses in motion, help heal wounds and cleanse the tissue. Unfortunately, however, they also cause damage in some diseases. To find out whether this also applies to age-related nerve degeneration, the scientists performed an experiment on mice. "For this purpose, we looked more closely at the nerves of 24-month-old mice which is an advanced age for mice," Rudolf Martini explains. It turned out that the age-related changes in the mice's peripheral nerves are very similar to those in humans. As in their human counterparts, the number of macrophages was increased in the mice. Also, the older animals had less strength than their younger siblings and their motor endplates, the synapses connecting nerves and muscle fibres, were also less intact.

Why It Matters How You Think About Pain | Outside Online

But the most interesting data deals with the difference between “adaptive” and “maladaptive” pain coping strategies. Adaptive strategies are things like ignoring pain, deciding that you won’t let it bother you, or overriding it with the urge to keep going. Maladaptive strategies are things like catastrophizing (“I’m going to have to drop out!”), fear (“It’s going to keep getting worse!”), and despondence (“This is awful!”). Each athlete was assigned daily composite scores of zero to six for adaptive and maladaptive coping, with zero corresponding to “never” and six corresponding to “always,” Alschuler says, reflecting “the extent to which the person is having thoughts that exemplify being willing to coexist with their pain versus the extent to which they are viewing their pain as a barrier that is difficult to overcome.” Overall, the ultrarunners were remarkably good at relying on adaptive coping (3.04 out of six, on average) rather than maladaptive coping (1.31 out of six). If that wasn’t the case, they probably would never have made it to one of these grueling races. Still, there were some interesting findings. For example, when runners used more than their usual level of maladaptive coping, they reported a greater perception that pain was interfering with their performance—even when the actual level of reported pain was held constant. They also spent more time thinking about their pain, which should be a reminder that sometimes it’s best not to dwell on it. The other interesting finding was a link between the use the maladaptive coping and the probability that a runner would finish the race. For every one-point increase in the maladaptive score, a runner’s likelihood of finishing the race dropped by a factor of three.

Why head and face pain causes more suffering: Sensory neurons in the head and face tap directly into the brain's emotional pathways -- ScienceDaily

The team found that sensory neurons that serve the head and face are wired directly into one of the brain's principal emotional signaling hubs. Sensory neurons elsewhere in the body are also connected to this hub, but only indirectly. The results may pave the way toward more effective treatments for pain mediated by the craniofacial nerve, such as chronic headaches and neuropathic face pain. "Usually doctors focus on treating the sensation of pain, but this shows the we really need to treat the emotional aspects of pain as well," said Fan Wang, a professor of neurobiology and cell biology at Duke, and senior author of the study. The results appear online Nov. 13 in Nature Neuroscience.

Even open-label placebos work, if they are explained -- ScienceDaily

For the first time, researchers from the University of Basel, along with colleagues from Harvard Medical School, have compared the effects of administering open-label and deceptive placebos. The team conducted an experimental study with 160 healthy volunteers who were exposed to increasing heat on their forearm via a heating plate. The participants were asked to manually stop the temperature rise as soon as they could no longer stand the heat. After that, they were given a cream to relieve the pain. Some of the participants were deceived during the experiment: they were told that they were given a pain relief cream with the active ingredient lidocaine, although it was actually a placebo. Other participants received a cream that was clearly labeled as a placebo; they were also given fifteen minutes of explanations about the placebo effect, its occurrence and its effect mechanisms. A third group received an open-label placebo without any further explanation. The subjects of the first two groups reported a significant decrease in pain intensity and unpleasantness after the experiment. "The previous assumption that placebos only work when they are administered by deception needs to be reconsidered," says Dr. Cosima Locher, a member of the University of Basel's Faculty of Psychology and first author of the study.

Why Do Rich People Love Endurance Sports? | Outside Online

“By flooding the consciousness with gnawing unpleasantness, pain provides a temporary relief from the burdens of self-awareness,” write the researchers. “When leaving marks and wounds, pain helps consumers create the story of a fulfilled life. In a context of decreased physicality, [obstacle course races] play a major role in selling pain to the saturated selves of knowledge workers, who use pain as a way to simultaneously escape reflexivity and craft their life narrative.”

Bring On the Exercise, Hold the Painkillers - The New York Times

It found that by reducing the production of prostaglandins, NSAIDs change how a body responds to exertion, this time deep within the muscles. For that study, researchers in the department of microbiology at Stanford University looked first at muscle cells and tissue from mice that had experienced slight muscular injuries, comparable to those we might develop during strenuous exercise. The tissue soon filled with a particular type of prostaglandin that turned out to have an important role: It stimulated stem cells within the muscles to start multiplying, creating new muscle cells that then repaired the tissue damage. Afterward, tests showed that the healed muscle tissue was stronger than it had been before.

Power of shared pain triggers extreme self-sacrifice -- ScienceDaily

There were five hypotheses: shared experience promotes willingness to perform extreme pro-group action; shared negative experiences make individuals contribute more than euphoric experiences; the more intense the experience the stronger the pro-social effects; the effect of shared negative experiences on pro-social behavior is much stronger where groups compete directly against other groups rather than if they cooperate against nature; and the effects of shared negative experience can be stronger than those of kinship. The hypotheses were then tested empirically in a variety of different study populations, including U.S. military veterans of the Vietnam war, college fraternity and sorority members who had undergone hazing, English Premier League football fans, martial arts practitioners of Brazilian Jiu Jitsu who sometimes use painful belt-whipping, and twins to examine the level of fusion. From both the theoretical and empirical research, the study concluded that overall shared negative experiences are a powerful mechanism for promoting pro-social behaviors, which under certain conditions can be extremely costly to the individuals concerned.

Opioids produce analgesia via immune cells: Researchers from the Charité find new signaling pathway -- ScienceDaily

"We were able to show that opioid agonists activate opioid receptors on immune cells, which triggered the release of endogenous painkillers (opioid peptides) and produced analgesia in a mouse model of neuropathic pain," explains Prof. Machelska. She adds, "This led us to conclude that opioids can exert enhanced analgesia when they act directly in painful tissue -- providing that this tissue is inflamed and contain immune cells."

Pain tolerance predicts human social network size : Scientific Reports

Animal awareness of others' needs

As long ago as 1959, Russell Church of Brown University set up a test which allowed laboratory rats in half of a cage to get food by pressing a lever. The lever also delivered an electric shock to rats in the other half of the cage. When the first group realised that, they stopped pressing the lever, depriving themselves of food. In a similar test on rhesus monkeys reported in the American Journal of Psychiatry in 1964, one monkey stopped giving the signal for food for 12 days after witnessing another receive a shock. There are other examples of animals preferring some sort of feeling over food.