Recent quotes:

Vitamin stops the aging process of organs: Nicotinamide riboside rejuvenates stem cells, allowing better regeneration processes in aged mice -- ScienceDaily

This is why the researchers wanted to "revitalize" stem cells in the muscles of elderly mice. And they did so by precisely targeting the molecules that help the mitochondria to function properly. "We gave nicotinamide riboside to 2-year-old mice, which is an advanced age for them," said the researcher. "This substance, which is close to vitamin B3, is a precursor of NAD+, a molecule that plays a key role in mitochondrial activity. And our results are extremely promising: muscular regeneration is much better in mice that received NR, and they lived longer than the mice that didn't get it."

The Morality of Language

In 1986, Michael Bond and Tat-ming Lai found that Chinese-English bilinguals were more open to discussing embarrassing topics, such as intimate sexual information, when chatting in their non-native language. And in 2010 Jean-Marc Dewaele found that multilinguals from the United Kingdom preferred swearing in their second language, claiming that it allowed them to escape from cultural and social restrictions.

What Happens Next Will Amaze You

Here is Bill Maris, of Google Ventures. This year alone Bill gets to invest $425 million of Google's money, and his stated goal is to live forever. He's explained that the worst part of being a billionaire is going to the grave with everyone else. “I just hope to live long enough not to die.” I went to school with Bill. He's a nice guy. But making him immortal is not going to make life better for anyone in my city. It will just exacerbate the rent crisis. Here's Elon Musk. In a television interview this week, Musk said: "I'm trying to do useful things." Then he outlined his plan to detonate nuclear weapons on Mars. These people are the face of our industry. Peter Thiel has publicly complained that giving women the vote back in 1920 has made democratic capitalism impossible. He asserts that "the fate of our world may depend on the effort of a single person who builds or propagates the machinery of freedom that makes the world safe for capitalism." I'm so tired of this shit. Aren't you tired of this shit?

Cell aging slowed by putting brakes on noisy transcription

"We used budding yeast, a single-cell organism, to study the epigenetic regulation of aging and this simple model turned out to be quite powerful," explained Sen. In yeast, aging is measured by the number of times a mother cell divides to form daughters before it stops. This number - a mean of 25 divisions -- is under tight control and can be either reduced or increased by altering histone modifications, as the researchers found. They showed that when fewer chemical groups of a certain type attach to yeast histones, the abnormal transcription greatly increases in old cells. In contrast, the team found that in yeast strains with a certain enzyme deletion, this abnormal transcription is reduced and lifespan is extended by about 30 percent. "We have started investigating whether such a longevity pathway can also be demonstrated in mammalian cells", says Berger. "However, these investigations are confounded by the complexity of the genome in more advanced organisms. One of our long-term goals is to design drugs that can help retain these beneficial histone modifications and extend healthy lifespan in humans."

Scientists reverse aging in human cell lines and give theory of aging a new lease of life -- ScienceDaily

The Tsukuba team in particular has performed some compelling research that has led them to propose that age-associated mitochondrial defects are not controlled by the accumulation of mutations in the mitochondrial DNA but by another form of genetic regulation. The research, published this month in the journal Nature's Scientific Reports, looked at the function of the mitochondria in human fibroblast cell lines derived from young people (ranging in age from a fetus to a 12 year old) and elderly people (ranging in age from 80-97 years old). The researchers compared the mitochondrial respiration and the amount of DNA damage in the mitochondria of the two groups, expecting respiration to be reduced and DNA damage to be increased in the cells from the elderly group. While the elderly group had reduced respiration, in accordance with the current theory, there was, however, no difference in the amount of DNA damage between the elderly and young groups of cells. This led the researchers to propose that another form of genetic regulation, epigenetic regulation, may be responsible for the age-associated effects seen in the mitochondria.