Stress and hippocampus
Research in the neurological literature for years has shown changes in the hippocampus when one has experienced long stress – so a release of hormones such as cortisol actually causes damage to the hippocampus.
But as it turns out, it may be that damage to the hippocampus also regulates one’s stress response – and that could contribute to the onset of depression. Again, it’s another one of these vicious cycles.
We have a list of 100 potentially stressful events – divorce, moving house, losing loved ones, etc. We found that our group of depressed individuals had not experienced more stressful events in their lives – but they had experienced them as more stressful.