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Insulin resistance may lead to faster cognitive decline: Executive function, memory are particularly vulnerable to the effects of insulin resistance, researchers say -- ScienceDaily

nsulin resistance is a condition in which cells fail to respond normally to the hormone insulin. The resistance prevents muscle, fat, and liver cells from easily absorbing glucose. As a result, the body requires higher levels of insulin to usher glucose into its cells. Without sufficient insulin, excess glucose builds up in the bloodstream, leading to prediabetes, diabetes, and other serious health disorders. The scientists followed a group of nearly 500 patients with existing cardiovascular disease for more than two decades. They first assessed the patients' baseline insulin resistance using the homeostasis model assessment (HOMA), calculated using fasting blood glucose and fasting insulin levels. Cognitive functions were assessed with a computerized battery of tests that examined memory, executive function, visual spatial processing, and attention. The follow-up assessments were conducted 15 years after the start of the study, then again five years after that. The study found that individuals who placed in the top quarter of the HOMA index were at an increased risk for poor cognitive performance and accelerated cognitive decline compared to those in the remaining three-quarters of the HOMA index. Adjusting for established cardiovascular risk factors and potentially confounding factors did not diminish these associations.

Cellular jetlag seems to favor the development of diabetes -- ScienceDaily

studied pancreatic ɑ- and β- cells that are in charge of the production of insulin and glucagon, two hormones that regulate glucose levels in the blood. They discovered that already at cellular levels, these internal clocks orchestrate the timing of proper hormone secretion, thus optimizing body metabolism by anticipating the rest-activity and feeding-fasting cycles. Their misalignment would thus favor the occurrence of metabolic diseases. Their discovery, to be read in the journal Genes and Development, highlights an essential factor, yet still poorly understood, which may explain diabetes development as a consequence of circadian misalignments of these cellular clocks.

Study finds wearables may help detect serious illness | MobiHealthNews

Led by geneticist Dr. Michael Snyder, researchers looked at 2 billion measurements from 60 people. Study participants wore between one and seven commercially available activity trackers (including Masimo, Basis and Scanadu) and other monitors, which were compared to the university’s standard clinical vital signs monitors. The devices collected 250,000 measurements per day, and researchers worked to establish a baseline range of values for each participant by collecting essential data like weight, heart rate, skin temperature, sleep, activity and caloric burn and exposure to gamma rays and X-rays. From there, the Stanford team was able to monitor deviations from each person’s normal baseline and associate the changes with environmental conditions (like flying in an airplane), illness, and other health-impacting factors. The team found two health-related observations – wearables were useful in identifying the onset of Lyme disease and inflammation, allowing them to build an algorithm for personalized disease detection using wearable sensors. They also found the sensors can reveal physiological differences between insulin sensitive and insulin-resistant people, meaning they could have the potential to help identify those at risk for type 2 diabetes.

Modest physical activity associated with improvement in markers, data suggests -- ScienceDaily

Researchers at the Boston University School of Medicine (BUSM) sought to examine the relationship of physical activity and inactivity, to insulin resistance and biomarkers of inflammation. Participants were asked to wear accelerometers during the day to estimate the amount of physical activity, as well as time spent being less active ("sedentary time"). These measurements were then compared to chemical markers of insulin resistance, inflammation and metabolism found in blood. They found that increased levels of physical activity (below what is required for weight loss) were associated with decreased insulin resistance as well as biomarkers of inflammation. The researchers also demonstrated that among individuals who spent more time sedentary, their blood contained higher levels of leptin, a chemical produced in fatty tissue that causes satiety, and FABP4 (fatty acid binding protein 4), a protein involved in the transport of fat molecules.

How to Avoid Becoming Diabetic

For almost a decade, Swedish GP Dr. Andreas Eenfeldt has been counseling his pre-diabetes, T2 diabetes, and obese patients to switch to a low-carb, high-fat diet. “In weeks and months they got better, their diabetes reversed and they could get off drugs,” said Dr Eenfeldt, who in 2007 started a non-commercial Swedish website, In 2010 his book Low Carb High Fat Food Revolution became a Swedish bestseller and was translated into eight languages. In 2011, he started the English site.

Oxytocin, diabetes and mental health

OT system dysfunction may be one common mechanism underlying MetS and psychotic disorders.