Behavioral nudges lead to striking drop in prescriptions of potent antipsychotic -- ScienceDailyThe study was a randomized controlled trial targeting the 5,055 highest Seroquel-prescribing primary care physicians nationwide in the Medicare Part D (prescription drug coverage) program in 2013 and 2014. A random half of the doctors were assigned to the treatment arm and received 3 letters comparing their prescribing practices to their peers; the other half received placebo letters about an unrelated Medicare regulation. The treatment arm's letter stated that the physician's prescribing of quetiapine high relative to their peers was under review. The text also discussed that high quetiapine prescribing could be appropriate but was concerning for medically unjustified use. The letter encouraged primary care physicians to review their prescribing patterns. The physicians who got the peer comparison letters dropped their overall Seroquel prescribing by 11 percent over the next 9 months and 16 percent over the next 2 years. New initiations of Seroquel dropped even more: 24 percent over 2 years.